Urinary Tartaric Acid, a Biomarker of Wine Intake, Correlates with Lower Total and LDL Cholesterol
Postmenopausal women are at higher risk of developing cardiovascular diseases due to changes in lipid profile and body fat, among others. The aim of this study was to evaluate the association of urinary tartaric acid, a biomarker of wine consumption, with anthropometric (weight, waist circumference, body mass index (BMI), and waist-to-height ratio), blood pressure, and biochemical variables (blood glucose and lipid profile) that may be affected during the menopausal transition.
This sub-study of the PREDIMEDThe PREDIMED study is one of the few randomized controlled trials about the Mediterranean Diet. More... (Prevencion con Dieta Mediterranea) trial included a sample of 230 women aged 60-80 years with high cardiovascular risk at baseline. Urine samples were diluted and filtered, and tartaric acid was analyzed by liquid chromatography coupled to electrospray ionization tandem mass spectrometry (LC-ESI-MS/MS).
Correlations between tartaric acid and the study variables were adjusted for age, education level, smoking status, physical activity, BMI, cholesterol-lowering, antihypertensive, and insulin treatment, total energy intake, and consumption of fruits, vegetables, and raisins.
A strong association was observed between wine consumption and urinary tartaric acid (0.01 mug/mg (95% confidence interval (CI): 0.01, 0.01), p-value < 0.001). Total and low-density lipoprotein (LDL) cholesterol were inversely correlated with urinary tartaric acid (-3.13 mug/mg (-5.54, -0.71), p-value = 0.016 and -3.03 mug/mg (-5.62, -0.42), p-value = 0.027, respectively), whereas other biochemical and anthropometric variables were unrelated. The results suggest that wine consumption may have a positive effect on cardiovascular health in postmenopausal women, underpinning its nutraceutical properties.
Additional Info
-
Authors
Dominguez-Lopez I.; Parilli-Moser I.; Arancibia-Riveros C.; Tresserra-Rimbau A.; Martinez-Gonzalez M. A.; Ortega-Azorin C.; Salas-Salvado J.; Castaner O.; Lapetra J.; Aros F.; Fiol M.; Serra-Majem L.; Pinto X.; Gomez-Gracia E.; Ros E.; Lamuela-Raventos R. M.; Estruch R. -
Issue
Nutrients. 2021 Aug; 13(8): 2883. -
Published Date
august 2021
Related items
- Reduced Alcohol Consumption and Major Adverse Cardiovascular Events Among Individuals With Previously High Alcohol Consumption
- Moderate wine consumption measured using the biomarker urinary tartaric acid concentration decreases inflammatory mediators related to atherosclerosis
- Moderate wine consumption measured using the biomarker urinary tartaric acid concentration decreases inflammatory mediators related to atherosclerosis
- Alcohol Consumption, High-Density Lipoprotein Particles and Subspecies, and Risk of Cardiovascular Disease: Findings from the PREVEND Prospective Study
- Effect of the Mediterranean diet in cardiovascular prevention